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Attenuating My Patient’s Chronic Allergies by Altering her Microbiome

Let me illustrate three important points about the gut and allergies and then discuss a patient who came to see me for chronic allergies.

  1. Specificity of probiotic strains matters. 

In a study by Luoto and colleagues (2010), high levels of the bacteria Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12 inside the gut were found to improve barrier function of the small and large intestines allowing reduced risk of common allergic diseases and intestinal infections. Supplements of these specific strains in children also led to long-term safety, unlike with most pharmaceutical drugs.  .  

  1. Modulation of the microbiome in early life can attenuate allergic disease.

While the mechanism of microbial composition/activity on allergy development is not concrete, diversity of the microbiome appears to be the law of the land. Sjögren and colleagues (2009) observed that children who were eventually diagnosed with allergies were significantly less likely to be colonized with strains of L. rhamnosus, L. casei, L. paracasei, B. adolescentis and Clostridium difficile two months post birth. This would indicate that greater microbial diversity early in life, if balanced with beneficial strains, likely prevent allergy development.

  1. After being weaned from breast milk, expose, expose, expose!

Introduction of food (and pollen) is all about timing. It's the context in which this first introduction has the biggest impact on allergy development—the context (diet of the mother, breast or formula fed, rural or urban home environment, exposure to pets or no exposure, etc.) sets the stage for the allergic state of the individual.

With this background information, see if you can guess what was wrong with a young student named Carmen who came to Advanced Health this summer for chronic allergies. 

One of the first things she told me was that she had felt anxious her whole life. By the time Carmen entered high school she had been started on an SSRI antidepressant.   SSRI’s are known to negatively impacted gut function and led to excess weight gain for Carmen.

A few years later, Carmen was diagnosed with Irritable Bowel Syndrome (IBS) as a result of her already damaged gut function.  Her symptoms of severe bloating, nausea, abdominal pain, and diarrhea were exacerbated during a trip to Latin America, and she was treated with multiple rounds of potent antibiotics. During this time, Carmen was diagnosed with a large benign thyroid mass and many food allergies (i.e., dairy, red meat, eggs, poultry, fish, wheat, potatoes, sweet potatoes).  Carmen had to do something to stop from getting sicker. 

During my first appointment with Carmen her history alone indicated a low count of beneficial gut bacteria, and damaged intestinal cells. Urine toxicology tests showed extremely high levels of dangerous herbicide Round- Up (glyphosate), along with the carcinogen Acrylamide (found in plastics, agrochemicals, and when consuming foods and drinks cooked at high temperatures). Carmen also had extremely levels of toxins derived from multiple mold species (Chaetoglobosin A, Ochratoxin A, citrinin, sterigmatocystin, and mycophenolic acid).  These mold species are often found in foods which require a great deal of water for production and must be sprayed heavily in order to withstand their long journey from agriculture to marketplace. The most common foods rich in mold are coffee, wheat, corn, soy, animal protein (i.e., dairy products, all meats, poultry, fish, eggs), nuts, dried fruit, and wine.  

We shifted Carmen to a plant-based diet full of fresh produce, with limited to no consumption of GMO crops (i.e., corn, soy, wheat), alcohol, and coffee.  Within two weeks Carmen’s chronic allergies remarkably improved and she could stop taking daily oral antihistamines. 

Carmen also began drinking more warm water and becoming more mindful of how and when she ate.  As her allergies symptoms dramatically decreased, Carmen was sleeping better and feeling more energized during the day.  Her mood became more hopeful and happy allowing her to decrease her antidepressant dose in 3 weeks. Within one month of us working together Carmen was no longer experiencing daily allergy symptoms and chronic digestive problems. She was over-the moon happy to stop taking her 15+ “natural” supplements and start seriously contemplating discontinuing her SSRI for good.  It was the first time in Carmen’s adult life she could imagine being off of medications and feeling good!

 

Dr. Bhandari and her Advanced Health Team Are Here to Support Your Health. Dr. Bhandari, M.D. and her Advanced Health team of experts work closely together to help patients like Carmen dramatically improve their gut health. They’re always ready to share their expertise on optimal gut repair and healing. To book an appointment, contact Advanced Health or call 1-415-506-9393.

 

 

References

Cuello-Garcia, C. A., Brożek, J. L., Fiocchi, A., Pawankar, R., Yepes-Nuñez, J. J., Terracciano, L., ... & Schünemann, H. J. (2015). Probiotics for the prevention of allergy: a systematic review and meta-analysis of randomized controlled trials. Journal of Allergy and Clinical immunology, 136(4), 952-961.

Luoto, R., Laitinen, K., Nermes, M., & Isolauri, E. (2010). Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study. British journal of nutrition, 103(12), 1792-1799. 

Nowak-Węgrzyn, A., & Chatchatee, P. (2017). Mechanisms of Tolerance Induction. Annals of Nutrition and Metabolism, 70(Suppl. 2), 7-24.

Sjögren, Y. M., Jenmalm, M. C., Böttcher, M. F., Björkstén, B., & Sverremark‐Ekström, E. (2009). Altered early infant gut microbiota in children developing allergy up to 5 years of age. Clinical & Experimental Allergy, 39(4), 518-526.

Author
Payal Bhandari M.D. Dr. Payal Bhandari M.D. Dr. Payal Bhandari M.D. is one of U.S.'s top leading integrative functional medical physicians and the founder of San Francisco' top ranked medical center, SF Advanced Health. Her well-experienced holistic healthcare team collaborates together to deliver whole-person personalized care and combines the best in Western and Eastern medicine. By being an expert of cell function, Dr. Bhandari defines the root cause of illness and is able to subside any disease within weeks to months. She specializes in cancer prevention and reversal, digestive & autoimmune disorders. Dr. Bhandari received her Bachelor of Arts degree in biology in 1997 and Doctor of Medicine degree in 2001 from West Virginia University. She the completed her Family Medicine residency in 2004 from the University of Massachusetts and joined a family medicine practice in 2005 which was eventually nationally recognized as San Francisco’s 1st patient-centered medical home. To learn more, go to www.sfadvancedhealth.com.

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